February 17, 2019

Diagnostic de l’intoxication digitalique et son traitement. Ferrero C. Author affiliations. Clinique universitaire de Médecine Interne, Hôpital Cantonal, Genève . Request PDF on ResearchGate | Intoxication digitalique en période néonatale: rôle de la déshydratation | Background Despite the great progress which has. Request PDF on ResearchGate | Intoxication digitalique massive. Traitement par hémoperfusion sur résine Amberlite XAD 4 | Haemoperfusion over amberlite.

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Digoxin immune Fab therapy in the management of digitalis intoxication: Open in a separate window.

Recognition and management of digitalis toxicity. Effect of ouabain and its interaction with diphenylhydantoin on cardiac arrhythmias induced by hypothalamic stimulation. This article has been cited by other articles in PMC. Abstract Recent reports of treatment of massive digoxin overdosage have emphasized the success of medical therapy.

The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties. The resurgence of symptoms of congestive heart failure and an immediate ventricular response in an Atrial Fibrillation AF context appears after the loss of the digoxin effect [10].

The digitalis glycosides constitute a homogeneous group of cardiotonics glycosides with different pharmacokinetic properties, digoxin is the digitalis currently used.

It is part of the arsenal therapeutic of atrial fibrillation, supraventricular tachycardia and congestive heart failure. Intoxicattion Inventory of Depressive Symptomatology. The clinical presentation of acute intoxication differs a little from that of a chronic intoxication. Allergic histories and reactions of patients treated with digoxin immune Fab ovine antibody.


The use of digoxin-specific Fab fragments for severe digitalis intoxication in patients. At higher concentrations, they increase the ventricular excitability. However, it remains under-used [8]. Behavior and Symptom Identification Scale. In fact, the intravenous lidocaine IV or phenytoin by either oral or intravenous controls effectively arrhythmias induced by the digitalis intoxication. Therefore, more calcium is digitaliwue in the sarcoplasmic reticulum, where more calcium is available to the next cellular depolarization and increase in the myocardial contraction Figure 2.

Voltage-time course and the effect of acetylcholine on atrial and nodal cells of the rabbit heart.

Massive digoxin ingestion. Report of a case and review of currently available therapies.

The repetition of doses is often necessary. The treatment is a temporary inhibition of digoxin under electrical supervision, a control of digoxinemia, monitoring and use of electrolytic supplements when needed. J Pharmacol Exp Ther. Figure 1 Mechanism of contraction of cardiomyocytes. If you are a subscriber, please sign in ‘My Account’ at the top right of the screen.

Massive digoxin ingestion. Report of a case and review of currently available therapies.

Journal List Br Heart J v. Despite our great familiarity with this molecule, its use requires a special attention since it has a narrow therapeutic index [1].

We also recall, that digitaliique is a large inter-individual variability in the response to the effect of digoxin. Finally, the anti digitalic antibodies can reverse the effect of digoxin in neutralizing its free fraction in serum and extracellular [5].

N Engl J Med 6: The treatment is based on the patient risk level. Equimolar Neutralization Semi-molar neutralization In the presence of a single pejorative factor: This text will be overwritten by jQuery.

Intoxication Digitalique

If you want to subscribe to this journal, see our rates You can purchase this item in Pay Per View: Arhythmia; Digoxin; Digitalis; Intoxication; Immunotherapy.


Once the diagnosis of intoxication digitalis dgitalique established, the treatment to use will depend on the degree of risk associated to the patient: This report describes a fatal outcome to this problem despite aggressive medical management, including pervenous cardiac pacing and draws attention digitaliqje deficiencies in current treatment of a serious problem.

Therefore, any process of dialysis would be effectively of limit. The digitalis intoxication may occur as a result of a drug interaction Table 2a use of supra-therapeutical doses or a decrease in renal elimination. Personal information regarding our website’s visitors, including their identity, is confidential. Table 1 Pharmacokinetic characteristics. Digestive disorders Vomiting is digitailque result of an excitatory action of digitalis glycosides on the postrema area.

Access to the full text of this article requires a subscription. The digibind study advisory panel. Am J Med Sci. Role of hypoxia in digitalis toxicity.

Treatment associated to low- risk situations will include temporary suspension of the therapy, ECG, follow-up and electrolytic supplements if necessary. Two components of the cardiac action potential. Drug interaction Mechanism and consequence of interaction All hypokalemic drugs diuretics, laxatives, corticosteroids, amphotericin B Increased toxicity of digitalis Calcium by injection Increased toxicity of digitalis Phenobarbital phenytoin Decreased plasma concentrations Table 2: Recent reports of treatment of massive digoxin overdosage have emphasized the success of medical therapy.

Am J Emerg Med 9: